Fecha/hora: 31/05/2024 22:13:07

Biblioteca(s): | INIA La Estanzuela.
Tipo de la producción científica: | Artículos en Revistas Indexadas Internacionales
Circulación/Nivel: | Internacional - --
Fecha corriente: | 08/06/2021
Fecha de la última actualización: | 02/09/2022
Autoria: | ESTEVEZ M.B.; CASAUX, M.L.; FRAGA, M.; FACCIO, R.; ALBORÉS, S.
Afiliación: | MARÍA BELÉN ESTEVEZ, Área de Microbiología, Departamento de Biociencias, Facultad de Química, Universidad de la República, Montevideo, Uruguay./Posgrado en Química, Facultad de Química, Universidad de la República, Montevideo, Uruguay.; MARÍA LAURA CASAUX, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARTIN FRAGA COTELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RICARDO FACCIO, Departamento de Experimentación y Teoría de la Estructura de la Materia y sus Aplicaciones (DETEMA), Facultad de Química, Centro NanoMat and Grupo Física, Universidad de la República, Montevideo, Uruguay.; SILVANA ALBORÉS, Area de Microbiología, Departamento de Biociencias, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Título: | Biogenic  silver nanoparticles as a strategy in the fight against multi-resistant salmonella enterica isolated from dairy calves.
Año de publicación: | 2021
Fuente/Imprenta: | Frontiers in Bioengineering and Biotechnology, April 2021, Volume 926, Article number 644014. OPEN ACCESS. Doi: https://doi.org/10.3389/fbioe.2021.644014
DOI: | 10.3389/fbioe.2021.644014
Idioma: | Inglés

Notas:

Article history:Received: 19 December 2020/Accepted: 31 March 2021/Published: 26 April 2021,
This work was supported by the Comisión Sectorial de Investigación Científica (CSIC), Espacio Interdisciplinario (EI) y Comisión Académica de Posgrado (CAP) (Universidad de la República, Uruguay), Program for the Development of Basic Sciences (PEDECIBA-Química), and Agencia Nacional de Investigación e Innovación (ANII) Uruguay.

Contenido: | Abstract: Infectious diseases are one of the most important health problems worldwide, one of the main causes being the development of multi-resistant microorganisms. Likewise,the zoonotic potential of some pathogens and their ability to transfer resistance mechanisms, reduce the therapeutic options in both humans and animals. Salmonella enterica is an important pathogen that affects a wide range of animal species and humans, being Salmonella Typhimurium one of the most frequent serotypes affecting cattle, causing enteritis, diarrhea, and septicemia. The search for alternative therapeutic approaches has gained importance since the emergence of multidrug resistance to antibiotics and periodic outbreaks of salmonellosis. In this sense, the discovery of new drugs and the development of new strategies, such as the use of nanoparticles with antimicrobial activity, are very promising. The aim of this work was the extracellular production of biogenic silver nanoparticles using fungal extracts and the evaluation of their antimicrobial activity against resistant and multi-resistant Salmonella Typhimurium strains. We here demonstrated the potential of the biogenic nanoparticles as effective bacteriostatic and bactericidal agents for use in biomedical applications. In addition, Confocal Raman Microscopy and Atomic Force Microscopy were used to advance the understanding of the antimicrobial mechanism of biogenic nanoparticles against these pathogenic strains, the results of which suggested that the nanoparticles produced damage in several bacterial cell structures.
Palabras-Clave: | Antimicrobial; Biogenic nanoparticles; Confocal Raman Microscopy; Multi-resistance; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL; Salmonella Typhimurium; TERNEROS LECHEROS.
Categoría del tema: | E16 Enfermedades de los animales

URL:

http://www.ainfo.inia.uy/digital/bitstream/item/16669/1/fbioe-09-644014.pdf
https://www.frontiersin.org/articles/10.3389/fbioe.2021.644014/pdf

Registro original: | INIA La Estanzuela (LE)
Ejemplares: | LE - (103382-1) - PXI - AP - DD - PP/FBB/abril 2021 -  -  - DIS